Diagnosis of CIN (CIN 1, CIN 2, CIN 3) is usually present in a smear test taken as a result of routine follow-up again in the presence of pap smear or HPV test is made by some of the cellular changes come. Sometimes I come out ASCUS smear test result is determined the further investigations. The cervix in a single region, usually called the transformation zone area itself is starting CIN is not cancer, cervical cancer, a lesion of the pioneer. CIN is usually classified into 3 degrees, and this classification with the top of the cervix known as epithelial tissue, is performed according to the depth of Diano. Epithelial surface 25% of the afflicted in the CIN 1 (mild dysplasia), 50% of the afflicted in the CIN 2 (moderate dysplasia) and 75% or more of the afflicted in the CIN 3 (severe dysplasia) are classified as. China in the form of light to pass through many years of heavy form is required. CIN 3 carcinoma in situ ‘, or the beginning of cervical cancer has advanced cancer of the cervix and eventually turns into. In recent years Bethesta system is used to classify the smear test, according to this system LSIL CIN 1 (CIN I)? corresponds to. HSIL is CIN 2 – CIN 3 (CIN II-CIN III) means. Usually with the pathology reports are both terms.
The problem of what are frequently observed in women with CIN?
There are different information about this and our country, unfortunately, very limited data on this topic. Further publications by the U.S. and some European countries in general CIN alınmaktadır.Toplumda in all degrees of incidence and the average age of onset of approximately 20-25% 2 ‘is. Today, the incidence of CIN with smear tests done regularly, even more frequent. For this reason, routine and regular smear tests done in terms of early diagnosis of a life saver for a woman. Today, unfortunately, of cervical cancer screening has never been half or more than 3 years or female physician control and smear (cancer screening) had intermediate test. In short, take out a regular smear test a possible cell change may occur very early detection and a means of cancer prevention.
CIN CIN consists of what is the reason why? Who is more at risk?CIN, cervical cancer is a disease of the pioneer. Stairs in the form of development, showing that a disease before starting with CIN I CIN II to CIN III after the ‘e, and ultimately cervical cancer (cervical cancer) becomes. The most important point in the course of the disease when placed on the diagnosis of CIN should be monitored on a regular basis. CIN of onset, age of onset is associated with women’s first sexual intercourse. In recent years, the incidence of CIN in women 16-19 years old, with some women at an early age to be sexually active has increased significantly. CIN to pass with sexual intercourse, often causing viruses. The last 10 years, studies of sexual intercourse and last the Human Papilloma virus (HPV), some types of CIN in playing a role in the formation have demonstrated definitively. HPV other than sexual contact with a herpes virus (HSV), which are publications of the genital herpes virus may play a role, but still more than the formation of the genital herpes virus suçlanmamaktadır CIN.
There are many risk factors for the formation of CIN. Polygamy and the two main independent risk factor for smoking. Possibility of cervical cancer seen in smokers, greater than 2-fold compared to nonsmokers. In addition, the cervix (cervical) cancer is thought to be a relationship between severity and number of cigarettes smoked. More than half a pack a day smoker olmaktadır.Düşük socioeconomic status and high degree of CIN to be suppressed immune system, malnutrition and other risk factors.
CIN What are the symptoms of the problem?
CIN cells the appearance of smear tests, cytologic examination
Contrary to popular belief does not symptom Cin. Coincidentally or visible result of a suspected smear test resulting in a cellular assessment. In some women, bleeding after sexual intercourse, the color constant bloody discharge, uterine mouth of the wound (erosion) may be signs of CIN or cervical cancer. Identification of abnormal cervical smears are reported frequently in the presence of neoplasm intraepitheliyal this finding is briefly described as CIN 3, Papanicolaou’s classification of sub-groups of Clas. Bethesda LSIL’e according to the classification of the CIN I, CIN II and CIN III is equal to the HSIL’e. Usually there are two explanations in the same report. The possible presence of ASCUS CIN (LSIL, HSIL), the problem might require further examination to be unutulmamalıdır.CIN I suspected mild, CIN II, moderate and severe dysplasia of the definitions of CIN III.
CIN is the course of disease? Is it always turns into cancer, CIN detected in each case?
CIN is important here? the degree. As the degree of CIN increases the risk of cancer. This varies from patient to patient progress and advance is not possible to determine when and how to proceed on the basis of other people. Another factor is whether or not the HPV virus and if you factor in the development of CIN caused by HPV virus is the type of HPV virus that what olduğudur.Düşük grade CIN (CIN 1) lesions usually regress. Turn into cancer CIN 1 ‘li (LSIL) patients were high risk HPV types. According to a study in CIN 1? The reason for the high-risk HPV types, CIN 3 in this lesion? showed that about 10% to the possibility of transformation. Without risk according to the study again with the same types of HPV CIN 1 CIN 3 and cancer, these lesions occurred in the dönüşmemektedirler. In short, CIN? S cancer-causing HPV virus depends on the type transformation. HPV types other than facilitating the progression of cancer in the CIN lesion is another factor in the region and the patient’s general condition occurred, the nature of the immune system. The front lip and the inner channel of the uterine cervix developing CIN is claimed to be more likely to turn into cancer cells.
What is the risk of cancer for the transformation of CIN 3 ’sort. CIN 3 (HSIL) detected 30-35% of women ‘after a while I turn into cancer. But this time there is no common view on how much time will be from person to person and the presence of HPV, HPV types varies. CIN 1 to CIN 3 in untreated? E, and the transformation of cancer in some women is 5-8 years, while other women, the same change again depending on the type of HPV and the effect of a very short period of time may be 1-2 years.
If the CIN is not treated, what is the result?
If the CIN is not treated, what is the result?
Of course, CIN 1, CIN 2 or CIN 3 is detected (Bethesta sistminde, LSIL, HSIL) should be done immediately without the necessary diagnostic tests and the problem should be treated further. However, the natural history of CIN is left without treatment and disappearance are decreased, and the same exposure, as well as moving are likely to turn into cancer. General speaking, the CIN of the possibility of disappearance decreased with increasing intensity is reduced, the increasingly likely to turn into cancer increases. Although it is not possible to determine in advance how to treat the disease is the presence of HPV is the most important factor is impressive considering that, if left untreated, 40-more than 60% of cases of spontaneous regression of CIN I, CIN III in 40% of cancer cases is estimated transformation. The presence of HPV type and the most important factor that can change all of these rates. CIN with HPV if you have cancer, unfortunately, the conversion may be faster and more.
When CIN should be detected?
Despite the different approaches in different centers, CIN (LSIL, HSIL) are almost identical to the logic of follow-up question. CIN detected smear test to women without the colposcopic examination, biopsy and endocervical curettage should be done. Some physicians prefer to follow up smears of women with CIN 1 weren general approach underlying the HPV type could pose a risk for rapid progression skip kolopskopi and biopsy is done. HPV is also done in the presence of HPV DNA typing is an option that might be right. Colposcopy and biopsy according to the results will be released by the degree of CIN (CIN 1, CIN 2 or CIN 3) or surgery, patients are treated according to the doctor’s decision.
How to treat CIN? What are the treatment of CIN preferences?
CIN 1 colposcopy with biopsy and definitive diagnosis in patients with the treatment of two different opinions as there are laid. Some physicians treat uygulamayıp smears and colposcopy to follow certain intervals, while some doctors prefer to treat, especially in the presence of HPV are preferred. Burning treatment (cauterization), freezing (cryotherapy), laser or LEEP konizasyon is preferred. These treatment methods in patients with CIN 1, and there is no superiority of any one can be selected. Another method of treatment for CIN 1 at birth if the patient has completed the pre-menopausal period, menopause or a hysterectomy as the measure (total abdominal hysterectomy) may be preferred. The decision belongs to the doctor and the patient also may be possible to apply different treatment options genellemeyip patient to patient. Treatment options at the beginning of the factors that determine the presence of HPV, HPV type and patient age.
CIN 2 and CIN 3 CIN 1 in the presence of the treatments applied in young patients, but strict follow-up of patients at high risk of conversion is alınır.Kansere birth if the woman completed the surgery in the womb and be one of the best treatment options. The most important factors that determine the treatment options for this group of patients, patient’s age and the presence of HPV. Treatment options for patients at all stages and made aware of possible risks and benefits of treatment should be given detailed information about.
What are the methods and options for the treatment of CIN?
* Cauterization (burning): Destruction by burning in the mouth of the womb with electrocautery (destruction) uğratılmasıdır. More preferred in the treatment of CIN 1 is one of the cheap and simple methods. Success rate is 80-90%. The most common method to be applied in cases of CIN 1 in our country.
* Cryotherapy (freezing): Nitrous oxide with abnormal cervical cells is frozen and destroyed. Conditions of practice could be done cheaper, faster and with less side-effects of a method. Recently, many gynecologists prefer this method even more. Colposcopy examination, lesions can be treated during the entire destruction of the visible and the most appropriate option. CIN 1 and CIN 2, which generally are preferred in appropriate patients. Success rate 80-90%? Is.
* Laser Ablation: CO2 laser for treatment of larger lesions, cryotherapy, or if the lesion is moving toward the uterine canal. Laser ablation can be performed with local anesthesia in the operating room or doctor’s office conditions. Laser ablation is the most common complication caused by bleeding. 80-90% chance of success of this treatment modality is. Widely used in our country.
* LEEP konizasyon: In recent years, due to both the therapeutic and also help make the diagnosis, the most popular and preferred method of treatment. CIN 1 patients refractory to other treatments, a simple, CIN 2 and CIN 3 as the first option is preferred in all patients. Surgery with local anesthesia or general anesthesia conditions in the operating room can be made. 90% success rate? is from. Be the first choice of treatment is recommended.
CIN follow-up treatment is done in what way?
After three months of treatment, Pap smears and colposcopy examination must wait yapılmalıdır.3 months after treatment with healing of the cervix are provided. Be a normal smear and colposcopic examination of the lesion seen previously as a result of the existing Pap smear 3? Er-month intervals is repeated two times. 3 normal Pap smear within a year to be the result indicates the success of treatment. Women with a history of CIN and cervical cancer are at high risk for the development of their lives as a continuation of the Pap smear should be repeated 6-12 months.
